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Blood films
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Blood Film Interpretation

It may be required of you to interpret blood films. Although students find this daunting, it is actually quite easy. It is necessary to memorise the appearance of the common abnormalities as well as the causes of these.

Target Cell

Thalassaemia, liver disease

Microcytic anaemia: Pale and Small

Find Those Small Cells : Fe deficiency, Thalassaemia, Sideroblastic, Chronic disease

Hypersegmented neutrophil (>7 lobules)

B12 deficiency. Subacute combined deficiency of the cord

Agglutination

Cold agglutin disease (autoimmune haemolytic anaemia)

Sickle cells

Sickle cell anaemia

Roleaux

Myeloma. Due to high protein

Reed Sternberg Cell

Hodgkins Lymphoma

Inclusion bodies/basophilic stippling

Lead poisoning

Signet rings

Malaria. Can only be in a few cells.

Atypical lymphocyte

Infection, often EBV

Tear drop cells

Myelofibrosis

Heinz bodies

Unstable Hbg state, often G6PD deficiency

Bite cell

G6PD deficiency

Leukoerythroblastic (immature rbcs, wbcs)

Bone marrow infiltration, myelofibrosis, sepsis, haemoloysis

Auer rod

Acute myeloid leukaemia

Howel Jolly bodies

Splenectomy, in haemolytic anaemia, in percicious anaemia, in thalassaemia, and in leukaemia

Ancanthocyte

Splenectomy, haemolytic anaemia, pernicious anaemia, thalassaemia, and in leukaemia
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