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Multiple Sclerosis

Signs Spastic paraparesis, cerebellar signs ± optic atrophy in young female
Differential diagnosis Demyelinating disease
Tests Vitamin B12 to exclude subacute degeneration
MR brain - hyperintense focal perventricular white matter lesions on T2 weighted
Lumbar puncture - raised total protein, oligoclonal bands
Serum electrophoresis - to exclude oligoclonal bands in serum

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